Conservation denotes the percentage of residues that match that of the rCRS among selected species. A query variant is depicted in isolation (i.e., other variants in a test sequence are not shown) and is flanked by rCRS reference for clarity.
| Species | -5 | -4 | -3 | -2 | -1 | 0 | +1 | +2 | +3 | +4 | +5 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Variant at rCRS pos 14459 (locus pos 72) of ND6 (light strand) | F | G | Y | T | T | V | M | A | I | E | E |
| Homo sapiens (rCRS) | F | G | Y | T | T | A | M | A | I | E | E |
| Alligator mississippiensis | F | A | F | C | V | G | F | T | D | D | P |
| Artibeus jamaicensis | F | G | Y | T | T | A | M | A | T | E | P |
| Balaenoptera musculus | F | G | Y | T | T | A | M | A | T | E | Q |
| Balaenoptera physalus | F | G | Y | T | T | A | M | A | T | E | Q |
| Bos taurus | F | G | Y | T | T | A | M | A | T | E | Q |
| Canis lupus familiaris | F | G | Y | T | T | A | M | A | T | E | Q |
| Cebus albifrons | F | G | Y | T | A | A | M | A | V | D | E |
| Ceratotherium simum | F | G | Y | T | T | A | M | A | T | E | Q |
| Cyprinus carpio | F | A | Y | A | A | - | L | A | A | E | P |
| Dasypus novemcinctus | F | G | Y | T | T | A | M | A | T | E | E |
| Didelphis virginiana | F | G | Y | T | T | A | M | A | T | E | E |
| Drosophila melanogaster | F | I | Y | V | T | S | L | A | S | N | E |
| Equus asinus | F | G | Y | T | T | A | M | A | T | E | Q |
| Equus caballus | F | G | Y | T | T | A | M | A | T | E | Q |
| Erinaceus europaeus | F | G | Y | T | A | A | M | A | M | E | E |
| Felis catus | F | G | Y | T | T | A | M | A | T | E | P |
| Gallus gallus | F | V | Y | S | V | S | L | A | A | D | P |
| Glis glis | F | G | Y | T | T | A | M | A | T | E | E |
| Gorilla gorilla | F | G | Y | T | T | A | M | A | I | G | E |
| Halichoerus grypus | F | G | Y | T | T | A | M | A | T | E | Q |
| Hippopotamus amphibius | F | G | Y | T | T | A | M | A | T | E | Q |
| Hylobates lar | F | G | Y | T | T | A | M | A | I | E | E |
| Loxodonta africana | F | G | Y | T | I | A | M | A | T | E | E |
| Macaca sylvanus | F | G | Y | T | M | A | M | A | I | E | E |
| Macropus robustus | F | G | Y | T | A | A | M | A | T | E | E |
| Mus musculus | F | G | Y | T | T | A | M | A | T | E | E |
| Nycticebus coucang | F | G | Y | T | T | A | M | A | T | E | E |
| Ornithorhynchus anatinus | F | G | Y | T | A | A | M | A | T | E | E |
| Oryctolagus cuniculus | F | G | Y | T | T | A | M | A | T | E | E |
| Ovis aries | F | G | Y | T | T | A | M | A | T | E | Q |
| Pan paniscus | F | G | Y | T | T | A | M | A | I | E | E |
| Pan troglodytes | F | G | Y | T | T | A | M | A | I | E | E |
| Papio hamadryas | F | G | Y | T | A | A | M | A | I | E | E |
| Phoca vitulina | F | G | Y | T | T | A | M | A | I | E | Q |
| Pongo abelii | F | G | Y | T | T | A | M | A | I | E | E |
| Pongo pygmaeus | F | G | Y | T | T | A | M | A | I | E | E |
| Rattus norvegicus | F | G | Y | T | T | A | M | A | T | E | E |
| Rhinoceros unicornis | F | G | Y | T | T | A | M | A | T | E | Q |
| Sciurus vulgaris | F | G | Y | T | T | A | M | A | T | E | E |
| Sus scrofa | F | G | Y | T | T | A | M | A | T | E | M |
| Talpa europaea | F | G | Y | T | T | A | M | A | M | E | E |
| Tarsius bancanus | F | G | Y | T | T | A | M | A | M | E | E |
| Vicugna pacos | F | G | Y | T | T | A | M | P | T | E | Q |
| Xenopus laevis | F | A | Y | S | A | - | A | R | A | K | P |