Conservation denotes the percentage of residues that match that of the rCRS among selected species. A query variant is depicted in isolation (i.e., other variants in a test sequence are not shown) and is flanked by rCRS reference for clarity.
| Species | -5 | -4 | -3 | -2 | -1 | 0 | +1 | +2 | +3 | +4 | +5 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Variant at rCRS pos 13094 (locus pos 253) of ND5 | H | S | S | T | M | A | V | A | G | I | F |
| Homo sapiens (rCRS) | H | S | S | T | M | V | V | A | G | I | F |
| Alligator mississippiensis | H | S | S | T | M | V | V | A | G | I | F |
| Artibeus jamaicensis | H | S | S | T | M | V | V | A | G | I | F |
| Balaenoptera musculus | H | S | S | T | M | V | V | A | G | I | F |
| Balaenoptera physalus | H | S | S | T | M | V | V | A | G | I | F |
| Bos taurus | H | S | S | T | M | V | V | A | G | I | F |
| Canis lupus familiaris | H | S | S | T | M | V | V | A | G | V | F |
| Cebus albifrons | H | S | S | T | M | V | V | A | G | V | F |
| Ceratotherium simum | H | S | S | T | M | V | V | A | G | V | F |
| Cyprinus carpio | H | S | S | T | M | V | V | A | G | I | F |
| Dasypus novemcinctus | H | S | S | T | M | V | V | A | G | I | F |
| Didelphis virginiana | H | S | S | T | M | V | V | A | G | I | F |
| Drosophila melanogaster | H | S | S | T | L | V | T | A | G | V | Y |
| Equus asinus | H | S | S | T | M | V | V | A | G | V | F |
| Equus caballus | H | S | S | T | M | V | V | A | G | V | F |
| Erinaceus europaeus | H | S | S | T | M | V | V | A | G | I | F |
| Felis catus | H | S | S | T | M | V | V | A | G | V | F |
| Gallus gallus | H | S | S | T | M | V | V | A | G | I | F |
| Glis glis | H | S | S | T | M | V | V | A | G | V | F |
| Gorilla gorilla | H | S | S | T | M | V | V | A | G | V | F |
| Halichoerus grypus | H | S | S | T | M | V | V | A | G | V | F |
| Hippopotamus amphibius | H | S | S | T | M | V | V | A | G | V | F |
| Hylobates lar | H | S | S | T | M | V | V | A | G | V | F |
| Loxodonta africana | H | S | S | T | M | V | M | A | G | V | F |
| Macaca sylvanus | H | S | S | T | M | V | V | A | G | V | F |
| Macropus robustus | H | S | S | T | M | V | V | A | G | I | F |
| Mus musculus | H | S | S | T | M | V | V | A | G | I | F |
| Nycticebus coucang | H | S | S | T | M | V | V | A | G | V | F |
| Ornithorhynchus anatinus | H | S | S | T | M | V | V | A | G | I | F |
| Oryctolagus cuniculus | H | S | S | T | M | V | V | A | G | V | F |
| Ovis aries | H | S | S | T | M | V | V | A | G | I | F |
| Pan paniscus | H | S | S | T | M | V | V | A | G | V | F |
| Pan troglodytes | H | S | S | T | M | V | V | A | G | I | F |
| Papio hamadryas | H | S | S | T | M | V | V | A | G | V | F |
| Phoca vitulina | H | S | S | T | M | V | V | A | G | V | F |
| Pongo abelii | H | S | S | T | M | V | V | A | G | V | F |
| Pongo pygmaeus | H | S | S | T | M | V | V | A | G | I | F |
| Rattus norvegicus | H | S | S | T | M | V | V | A | G | I | F |
| Rhinoceros unicornis | H | S | S | T | M | V | V | A | G | V | F |
| Sciurus vulgaris | H | S | S | T | M | V | V | A | G | I | F |
| Sus scrofa | H | S | S | T | M | V | V | A | G | V | F |
| Talpa europaea | H | S | S | T | M | V | V | A | G | V | F |
| Tarsius bancanus | H | S | S | T | M | V | V | A | G | V | F |
| Vicugna pacos | H | S | S | T | M | V | V | A | G | V | F |
| Xenopus laevis | H | S | S | T | M | V | V | A | G | I | F |